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    Home » Recipes » Main Dish/Entrée

    John Wayne Casserole Recipe {Video}

    Published: Mar 11, 2021 · This post may contain affiliate links

    John Wayne Casserole is an easy ground beef casserole that is filled with flavor! It has a biscuit base and is loaded with diced tomatoes, onions, cheese, sour cream, taco seasoning, and more cheese! This is one of our favorite easy ground beef casseroles to make for dinner.

    John Wayne Casserole

    Contents show
    John Wayne Casserole
    How to make John Wayne Casserole
    Great Dinner Recipes
    John Wayne Casserole Recipe
    Ingredients
    Instructions
    Nutrition

    This is truly one of our favorite ground beef comfort food dinners. When I have hamburger ground beef in the fridge that I need to use this is the recipe I work on. I love that you can customize it based on what you have in the house.

    This casserole is similar to a beef fajita but in casserole form. I change up what I put in this casserole based on what we have available. This is one of those beef casserole dishes you can easily change based on what you and your family enjoys.

    I love that it has a Bisquick baking mix base that turns out amazing. It is amazing all of the things you can make with Bisquick Mix. We have been making Bisquick Waffles, Bisquick Peach Cobbler, Pancake Muffins, and Bisquick beer bread just to name a few things.

    We started buying giant boxes of Bisquick from Costco we have been using it so much. It is so versatile and always tastes amazing.

    Ingredients

    • Ground Beef
    • Taco Seasoning
    • Rotel Diced Tomatoes and Green Chilies
    • Corn
    • Bisquick Biscuit Mix
    • Sour Cream
    • Cream Cheese
    • Cheddar Cheese
    • Mayo
    • Green Bell Peppers or red bell pepper

    Ground Beef - You can easily change this from ground beef to ground turkey, ground chicken, or a meat alternative like Beyond Beef.

    Taco Seasoning - I use 1 regular taco seasoning mix from the grocery store.

    Rotel Diced Tomatoes and Green Chilies - I used a mild version of Rotel but you can easily use spicy or other versions.

    Bisquick Baking Mix - You can easily use gluten-free Bisquick if you are gluten intolerant.

    Cheddar cheese - feel free to change out the cheddar cheese for Colby jack, mozzarella, pepper jack cheese or any mix of cheeses.

    Onions - I didn't add onions into the recipe because I ran out. You can easily add in a cup of diced onions and cook the onions with the ground beef so they are soft.

    We do not have potatoes, tater tots, or tomato slices in our John Wayne Casserole Recipe. I am not sure if the original John Wayne Casserole Recipe had these variations.

    Equipment needed

    Large Skillet

    Large Spoon

    Large Mixing Bowl - We are big fans of this glass batter bowl that has a handle. It makes it easy to mix ingredients and keeps the mixing bowl steady on the counter.

    Hamburger Chopper - I love to use the hamburger mix and chop to break up ground beef while it is cooking. I honestly use this tool with a ton of recipes. It is one of my most used kitchen tools.

    9 X 13 inch baking dish

    Heat resistant potholders - A couple of years ago we had a fire scare when we didn't realize we had turned a burner on and a cloth potholder caught fire. Thankfully we walked by the kitchen and saw the smoke and were able to get it out ourselves. Since then we have only used these heat-resistant potholders.

    Non-stick cooking spray - I use nonstick spray on the casserole dish to make it easier to serve and also on my hands when I am pushing the Bisquick dough into the casserole dish.

    Spider Strainer - I love using a spider strainer to easily drain the ground beef

    Baking Sheets - We are huge fans of these baking sheets with sides. They help contain any of the sour cream mixture that may ooze over the top of the dish as it cooks and the biscuit crust cooks.

    Recipe Tips

    Don't forget to pre-heat oven.

    You can add in extra green chilies if you would like this dish to be spicier. I serve it to my husband's mom and know that I will get a ton of side-eye if I make it too spicy.

    Feel free to add in diced red peppers

    If you don't have biscuit mix you can easily make this with Pillsbury Grands biscuits spread on the bottom of the baking dish.  Just make sure to push them together so they fill the pan. You will want to bake them for half their normal baking time to get them set in the bottom of the casserole dish before adding in the beef mixture.

    I highly suggest putting a baking sheet under your casserole dish in the oven. When the Bisquick dough bakes it pushes the other ingredients higher and higher in the dish and some of the toppings and/or casserole juices may spill over the side.

    This recipe is featured in our cream cheese recipes collection

    How to make John Wayne Casserole

    Brown the beef and add taco seasoning and water. I use a Hamburger Chopper to break up the ground beef and mix in the packet taco seasoning.

    Use a spider strainer to remove the ground beef from the pan and drain the fat and grease out before adding the rest of the ingredients.

    Add in Rotel, canned corn, and cook together

    While this is cooking combine Bisquick biscuit mix and water in a mixing bowl until a soft dough ball forms. Pat dough into the bottom of a greased casserole dish.

    Top biscuit dough with the browned ground beef and veggies and spread it evenly over the dough.

    In a separate bowl combine sour cream and mayonnaise together until smooth. Spread cream cheese mixture over the brown ground beef

    Top with cheddar cheese and bake! I highly suggest putting a baking sheet under the casserole dish to catch any drips or spills that may occur when this is baking. I fill my casserole dish to the top and it tends to drop over the side.

    One thing to take into consideration is when the Bisquick dough bakes the other layers of ingredients inch up the sides of the casserole dish.

    Allow the John Wayne Casserole to sit for a few minutes before serving.

    Great Dinner Recipes

    Chicken Bacon Ranch Casserole

    Million Dollar Spaghetti

    Ham and Cheese Crescent Roll Casserole

    Chicken Casserole with Ritz Crackers

    Pepperoni Pizza Monkey Bread

    Stovetop Meatloaf

    Lazy Lasagna

    Spaghetti Stuffed Garlic Bread

    Check out all of our Rotel Recipes and Bisquick Recipes 

    Do you love recipes? Check out our copy cat recipes, dessert recipes, and our Crock Pot Recipes.

    Follow Tammilee Tips on MSN, Facebook, Instagram, Pinterest, and Twitter for all of our recipe posts.

    Serving of John Wayne Casserole on a white plate

    John Wayne Casserole Recipe

    Delicious John Wayne Casserole is an easy ground beef casserole packed with flavor. A biscuit base is loaded with hamburger, tomatoes, chilies, taco seasoning, corn and cheese to make a flavorful delicious comfort food dinner.
    No ratings yet
    Print Rate
    Prep Time: 25 minutes minutes
    Cook Time: 40 minutes minutes
    Total Time: 1 hour hour 5 minutes minutes
    Servings: 8
    Calories: 904kcal
    Author: Tammilee Tips

    Ingredients

    • 1.5 pounds Ground Beef
    • 1 oz Taco seasoning
    • 1 cup Water
    • 20 oz RO-TEL Diced Tomatoes & Green Chilies 2 cans, drained
    • 15 oz Corn Drained
    • 1 Green Pepper Diced
    • 3 cups Bisquick Baking Mix
    • 1 cup Water
    • 1 cup Sour Cream
    • 1 cup Mayonnaise
    • 2 Tablespoon Onion powder
    • 1 teaspoon Salt
    • 3 cups Cheddar Cheese Shredded

    Instructions

    • Preheat Oven to 325 degrees
    • Brown ground beef in a large pan over medium heat. Break up the ground beef as it cooks
    • Remove the ground beef and drain the grease from the pan. Add the ground beef back into the pan and top with taco seasoning and add in 1 cup of water.
    • Simmer for 5 minutes. Add in the Rotel, Green Pepper, and Corn and mix into the ground beef.
    • Combine Bisquick Baking Mix and Water and stir until a dough ball forms.
    • Grease a 9x13 pan with nonstick spray. Spread Bisquick dough out evenly into the pan.
    • Combine sour cream, mayonaise, onion poweder, and salt in a bowl and mix together. Set to th side
    • Pour ground beef mixture over the bisquick dough and spread evenly. Spread sour cream mayo mixture over the beef mixture evenly. Top with cheddar cheese.
    • Place casserole dish on top of a baking sheet with sides and bake for 40 minutes. Remove casserole from the oven and allow to sit for a few minutes before serving.
    9X13 Pan
    Hamburger Mix and Chop
    Cookie Sheets

    Nutrition

    Nutrition Facts
    John Wayne Casserole Recipe
    Amount Per Serving
    Calories 904 Calories from Fat 594
    % Daily Value*
    Fat 66g102%
    Saturated Fat 24g150%
    Trans Fat 1g
    Cholesterol 132mg44%
    Sodium 1778mg77%
    Potassium 683mg20%
    Carbohydrates 48g16%
    Fiber 4g17%
    Sugar 12g13%
    Protein 32g64%
    Vitamin A 1234IU25%
    Vitamin C 24mg29%
    Calcium 469mg47%
    Iron 5mg28%
    * Percent Daily Values are based on a 2000 calorie diet.
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    About Tammilee

    Lifestyle blogger who travels the world and drinks too much Chai tea. Travel blogger, award winning photographer, sunset hunter, Birkenstock girl, bird nerd
    You can find Tammilee on Pinterest, Facebook, Twitter, and Instagram

    Reader Interactions

    Comments

    1. Patricia Stroud

      February 12, 2023 at 9:58 am

      Made the John Wayne casserole and loved it. Will try to 1/2 the ingredients next time as there is only two of us.

      Reply

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